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The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may possibly end in an increase in methadone plasma concentrations, which could trigger potentially fatal respiratory despair. Furthermore, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also resul